The next step would therefore be to assess the efficacy of microsurgical varicocelectomy in the case of subclinical varicocele. Semen parameters, including WHO and strict criteria morphology, in a fertile and subfertile population: Romijn, M. Correlation with clinical parametersSperm DNA damage may exert its effect at different stages of the reproductive procedure, beginning from the pre-implantation development of the embryo to the achievement and sustaining of pregnancy and finally the creation of healthy offspring.
Clinical Factors Associated with Sperm DNA Fragmentation in Male Patients with Infertility
There is indeed some controversy regarding the effect of sperm DNA fragmentation on fertilization rates. Chromosomal aberrations, Yq microdeletion, and sperm DNA fragmentation in infertile men opting for assisted reproduction. DNA damage in bovine sperm does not block fertilization and early embryonic development but induces apoptosis after the first cleavages. In case of compromised sperm DNA quality, apoptosis and fragmentation may also be present within the embryo and subsequently there is some difficulty in reaching to blastocyst stage